Design and development of novel non-peptide agonists at NPR-C
نویسندگان
چکیده
Background Endothelium-derived C-type natriuretic peptide (CNP) possesses cytoprotective and anti-atherogenic functions that regulate vascular tone and smooth-muscle relaxation and might be key in protecting against ischaemiareperfusion injury [1]. The finding that many of the vasoprotective effects of CNP are mediated by the natriuretic peptide receptor type-C (NPR-C) suggests that this receptor might represent a novel therapeutic target for the treatment of cardiovascular diseases. Thus, we have designed and developed small molecule druglike mimetics of CNP agonists at NPRC.
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